The urokinase‐type plasminogen activator system as drug target in retinitis pigmentosa: New pre‐clinical evidence in the rd10 mouse model

Por Cammalleri, Maurizio, Dal Monte, Massimo, Locri, Filippo, Pecci, Valeria, De Rosa, Mario, Pavone, Vincenzo, Bagnoli, Paola
Publicado no J Cell Mol Med (2019)

Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

Por Johnson, Amy J., Lucas, David M., Muthusamy, Natarajan, Smith, Lisa L., Edwards, Ryan B., De Lay, Michael D., Croce, Carlo M., Grever, Michael R., Byrd, John C.
Publicado em 2006

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype

Por Lyzogubov, Valeriy V., Bora, Puran S., Wu, Xiaobo, Horn, Leah E., de Roque, Ryan, Rudolf, Xeniya V., Atkinson, John P., Bora, Nalini S.
Publicado no Am J Pathol (2016)

A standardised framework to identify optimal animal models for efficacy assessment in drug development

Por S. Ferreira, Guilherme, Veening-Griffioen, Désirée H., Boon, Wouter P. C., Moors, Ellen H. M., Gispen-de Wied, Christine C., Schellekens, Huub, van Meer, Peter J. K.
Publicado no PLoS One (2019)

Mouse Adenovirus Type 1 Infection in SCID Mice: an Experimental Model for Antiviral Therapy of Systemic Adenovirus Infections

Por Lenaerts, L., Verbeken, E., De Clercq, E., Naesens, L.
Publicado em 2005

Synthesis, in vitro and in vivo evaluation of 3β-[(18)F]fluorocholic acid for the detection of drug-induced cholestasis in mice

Por De Lombaerde, Stef, Neyt, Sara, Kersemans, Ken, Verhoeven, Jeroen, Devisscher, Lindsey, Van Vlierberghe, Hans, Vanhove, Christian, De Vos, Filip
Publicado no PLoS One (2017)

Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains

Por Giles, Kurt, Berry, David B., Condello, Carlo, Hawley, Ronald C., Gallardo-Godoy, Alejandra, Bryant, Clifford, Oehler, Abby, Elepano, Manuel, Bhardwaj, Sumita, Patel, Smita, Silber, B. Michael, Guan, Shenheng, DeArmond, Stephen J., Renslo, Adam R., Prusiner, Stanley B.
Publicado no J Pharmacol Exp Ther (2015)

DDRE-19. SPIDER VENOMS AS SOURCES OF MOLECULES FOR NEW CANCER TREATMENTS: THE EFFECTS OF THE SNX-482 PEPTIDE ON MACROPHAGE MODULATION

Por de Lima Munhoz, Jaqueline, Thome, Rodolfo, Ishikawa, Larissa, dos Santos, Natalia Barreto, da Rocha-e-Silva, Thomaz A A, Sutti, Rafael, Verinaud, Liana, Araujo, João Luiz Vitorino, Rostami, Abdolmohamad, Raposo, Catarina
Publicado no Neuro Oncol (2020)

LPSF/GQ-02 Inhibits the Development of Hepatic Steatosis and Inflammation in a Mouse Model of Non-Alcoholic Fatty Liver Disease (NAFLD)

Por Soares e Silva, Amanda Karolina, de Oliveira Cipriano Torres, Dilênia, dos Santos Gomes, Fabiana Oliveira, dos Santos Silva, Bruna, Lima Ribeiro, Edlene, Costa Oliveira, Amanda, dos Santos, Laise Aline Martins, de Lima, Maria do Carmo Alves, Pitta, Ivan da Rocha, Peixoto, Christina Alves
Publicado no PLoS One (2015)

In Vitro Generation of Interleukin 10–producing Regulatory CD4(+) T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

Por Barrat, Franck J., Cua, Daniel J., Boonstra, André, Richards, David F., Crain, Chad, Savelkoul, Huub F., de Waal-Malefyt, René, Coffman, Robert L., Hawrylowicz, Catherine M., O'Garra, Anne
Publicado em 2002

Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization

Por Cheng, Benson Yee Hin, Ortiz-Riaño, Emilio, Nogales, Aitor, de la Torre, Juan Carlos, Martínez-Sobrido, Luis
Publicado no J Virol (2015)

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation

Por Sebastián-Serrano, Álvaro, Engel, Tobias, de Diego-García, Laura, Olivos-Oré, Luis A., Arribas-Blázquez, Marina, Martínez-Frailes, Carlos, Pérez-Díaz, Carmen, Millán, José Luis, Artalejo, Antonio R., Miras-Portugal, María Teresa, Henshall, David C., Díaz-Hernández, Miguel
Publicado no Hum Mol Genet (2016)

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

Por Liu, Zhong-Hua, Chuang, De-Maw, Smith, Carolyn Beebe
Publicado em 2010

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis

Por Lee, Noo Ri, Kim, Beom Jun, Lee, Chung Hyeok, Lee, Young Bin, Lee, Solam, Hwang, Hyun Jee, Kim, Eunjung, Kim, Sung Hee, Lee, Min-Geol, Lee, Sang Eun, Lavery, Gareth G., Choi, Eung Ho
Publicado no Sci Rep (2020)

The Tyrphostin Agent AG490 Prevents and Reverses Type 1 Diabetes in NOD Mice

Por Davoodi-Semiromi, Abdoreza, Wasserfall, Clive H., Xia, Chang Qing, Cooper-DeHoff, Rhonda M., Wabitsch, Martin, Clare-Salzler, Michael, Atkinson, Mark
Publicado em 2012

Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment.

Por Donald R Hoff, Gavin J Ryan, Emily R Driver, Cornelius C Ssemakulu, Mary A De Groote, Randall J Basaraba, Anne J Lenaerts
Publicado em 2011-03-01

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

Por Hoff, Donald R., Ryan, Gavin J., Driver, Emily R., Ssemakulu, Cornelius C., De Groote, Mary A., Basaraba, Randall J., Lenaerts, Anne J.
Publicado em 2011

Humanized mouse model: a review on preclinical applications for cancer immunotherapy

Por Yin, Ling, Wang, Xue-Jing, Chen, De-Xi, Liu, Xiao-Ni, Wang, Xiao-Jun
Publicado no Am J Cancer Res (2020)

Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT

Por Khmelinskii, Artem, Groen, Harald C., Baiker, Martin, de Jong, Marion, Lelieveldt, Boudewijn P. F.
Publicado em 2012

Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

Por Danovi, Davide, Meulmeester, Erik, Pasini, Diego, Migliorini, Domenico, Capra, Maria, Frenk, Ruth, de Graaf, Petra, Francoz, Sarah, Gasparini, Patrizia, Gobbi, Alberto, Helin, Kristian, Pelicci, Pier Giuseppe, Jochemsen, Aart G., Marine, Jean-Christophe
Publicado em 2004