In Vitro Generation of Interleukin 10–producing Regulatory CD4(+) T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells. In contrast to the previously described in vitro derived CD4(+) T cells, these cells produced only interleukin (IL)...

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Main Authors: Barrat, Franck J., Cua, Daniel J., Boonstra, André, Richards, David F., Crain, Chad, Savelkoul, Huub F., de Waal-Malefyt, René, Coffman, Robert L., Hawrylowicz, Catherine M., O'Garra, Anne
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193760/
https://ncbi.nlm.nih.gov/pubmed/11877483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011629
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