Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

Drug development in human chronic lymphocytic leukemia (CLL) has been limited by lack of a suitable animal model to adequately assess pharmacologic properties relevant to clinical application. A recently described TCL-1 transgenic mouse develops a chronic B-cell CD5(+) leukemia that might be useful...

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Autors principals: Johnson, Amy J., Lucas, David M., Muthusamy, Natarajan, Smith, Lisa L., Edwards, Ryan B., De Lay, Michael D., Croce, Carlo M., Grever, Michael R., Byrd, John C.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895879/
https://ncbi.nlm.nih.gov/pubmed/16670263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-011213
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