B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia

B cell chronic lymphocytic leukemia (B-CLL) is a clonal overgrowth of CD5(+) B lymphocytes. In this disease, the B cell antigen receptor (BCR) is intimately linked to disease severity, because patients with BCRs, comprised of unmutated V(H) genes, follow a much more aggressive course. This and relat...

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Detalhes bibliográficos
Main Authors: Yan, Xiao-jie, Albesiano, Emilia, Zanesi, Nicola, Yancopoulos, Sophia, Sawyer, Alan, Romano, Egidio, Petlickovski, Aleksandar, Efremov, Dimitar G., Croce, Carlo M., Chiorazzi, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518806/
https://ncbi.nlm.nih.gov/pubmed/16864779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604564103
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