Resultados da pesquisa - (( a nagy chirp can netw ) OR ((( 5 soil company can new ) OR ( a small compound a now ))))

141

Accelerating Multiple Compound Comparison Using LINGO-Based Load-Balancing Strategies on Multi-GPUs

Por Chun-Yuan Lin, Chung-Hung Wang, Che-Lun Hung, Yu-Shiang Lin
Publicado em 2015-01-01

“..., potential inhibitors can be found and then used for the pharmacy experiments. The time complexity of a...”
Obter o texto integral

Artigo

142

A carregar...

DEVELOPMENT OF NOVEL SMALL MOLECULES THAT TARGET GLIOBLASTOMA STEM CELLS

Por Kesari, Santosh, Tsigelny, Igor F., Mukthavaram, Rajesh, Kouznetsova, Valentina L., Chao, Ying, Pastorino, Sandra, Jiang, Pengfei, Pingle, Sandeep C., Wrasidlo, Wolf, Makale, Milan
Publicado em 2014

“... have identified a small molecule compound with significant in vitro/vivo anti-GBM activity...”
Obter o texto integral
Obter o texto integral

Artigo

143

A carregar...

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Por Kalra, Hina, Drummen, Gregor P. C., Mathivanan, Suresh
Publicado no Int J Mol Sci (2016)

“... them, a new frontier of signal transduction was discovered. These “extracellular vesicles” (EV) were...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

144

A carregar...

High-throughput screening and small animal models, where are we?

Por Giacomotto, Jean, Ségalat, Laurent
Publicado em 2010

“... in animal models. To by-pass these limitations, efforts are now being made to screen chemical libraries...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

145

A carregar...

Small Molecule Inhibitors of Human Papillomavirus Protein - Protein Interactions

Por D’Abramo, C.M, Archambault, J
Publicado em 2011

“...Human papillomaviruses (HPV) have now been identified as a necessary cause of benign and malignant...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

146

A carregar...

Small Molecule Inhibitors of Regulators of G Protein Signaling (RGS) Proteins

Por Turner, Emma M., Blazer, Levi L., Neubig, Richard R., Husbands, Stephen M.
Publicado em 2011

“... barrier permeable. A lead compound (1a) was identified as an inhibitor of RGS4 in a screening assay...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

147

A carregar...

Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection

Por Noueiry, Amine O., Olivo, Paul D., Slomczynska, Urszula, Zhou , Yi, Buscher, Ben, Geiss , Brian, Engle, Michael, Roth, Robert M., Chung , Kyung Min, Samuel, Melanie, Diamond, Michael S.
Publicado em 2007

“...West Nile virus (WNV) has spread throughout the United States and Canada and now annually causes a...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

148

A carregar...

Small Molecule Screen for Candidate Antimalarials Targeting Plasmodium Kinesin-5

Por Liu, Liqiong, Richard, Jessica, Kim, Sunyoung, Wojcik, Edward J.
Publicado em 2014

“..., resulting in over a million deaths annually. Malaria parasites now show measured resistance to all currently...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

149

A carregar...

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor Pifithrin-μ

Por Krukowski, Karen, Nijboer, Cora H., Huo, XiaoJiao, Kavelaars, Annemieke, Heijnen, Cobi J.
Publicado no Pain (2015)

“... with the small compound pifithrin-μ (PFT-μ) prevents cerebral neuronal death in a rodent model of hypoxic...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

150

A carregar...

Shutting Down the Pore: The Search for Small Molecule Inhibitors of the Mitochondrial Permeability Transition

Por Šileikytė, Justina, Forte, Michael
Publicado no Biochim Biophys Acta (2016)

“...The mitochondrial permeability transition pore (PTP) is now recognized as playing a key role in a...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

151

A carregar...

Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

Por Ambrus, Géza, Whitby, Landon R., Singer, Eric L., Trott, Oleg, Choi, Euna, Olson, Arthur J., Boger, Dale L., Gerace, Larry
Publicado em 2010

“... of the β-karyopherin family, also called importins and exportins. Leptomycin B, a small molecule inhibitor...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

152

A carregar...

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule...

Por El-Gazzar, Ahmed, Noppen, Sam, Thomas, Joice, Dehaen, Wim, Balzarini, Jan, Liekens, Sandra
Publicado no Oncotarget (2017)

“... reported the synthesis and anti-proliferative activity of a novel synthetic 2-aminothiophene-3-carboxylic...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

153

A carregar...

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

Por Jackson, Robert S., Creemers, John W.M., Farooqi, I. Sadaf, Raffin-Sanson, Marie-Laure, Varro, Andrea, Dockray, Graham J., Holst, Jens J., Brubaker, Patricia L., Corvol, Pierre, Polonsky, Kenneth S., Ostrega, Diane, Becker, Kenneth L., Bertagna, Xavier, Hutton, John C., White, Anne, Dattani, Mehul T., Hussain, Khalid, Middleton, Stephen J., Nicole, Thomasina M., Milla, Peter J., Lindley, Keith J., O’Rahilly, Stephen
Publicado em 2003

“... now report the second case of human PC1 deficiency (Subject B), also due to compound heterozygosity...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

154

A carregar...

Synthesis of many different types of organic small molecules using one automated process

Por Li, Junqi, Ballmer, Steven G., Gillis, Eric P., Fujii, Seiko, Schmidt, Michael J., Palazzolo, Andrea M. E., Lehmann, Jonathan W., Morehouse, Greg F., Burke, Martin D.
Publicado no Science (2015)

“...Small molecule synthesis usually relies on procedures highly customized for each target. A broadly...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

155

A carregar...

Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity

Por Sharlow, Elizabeth R., Mustata Wilson, Gabriela, Close, David, Leimgruber, Stephanie, Tandon, Manuj, Reed, Robyn B., Shun, Tong Ying, Wang, Q. Jane, Wipf, Peter, Lazo, John S.
Publicado em 2011

“... described cell-active PKD1 inhibitors while computational docking of the new cell-active compounds in a...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

156

A carregar...

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

Por Wang, Ran, Zhang, Qian, Peng, Xin, Zhou, Chang, Zhong, Yuxu, Chen, Xi, Qiu, Yuling, Jin, Meihua, Gong, Min, Kong, Dexin
Publicado no Sci Rep (2016)

“...Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

157

A carregar...

Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules

Por Kim, Jee Hye, Jung, Ye Jin, Choi, Byeol, Lee, Na Lim, Lee, Hae Jun, Kwak, Soo Yeon, Kwon, Youngjoo, Na, Younghwa, Lee, Yun-Sil
Publicado no Oncotarget (2016)

“... identified another small molecule, a xanthone compound, more capable of altering dimeric HSP27 than ZER...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

158

A carregar...

Identification of novel small molecules that inhibit protein–protein interactions between MAGE and KAP-1

Por Bhatia, Neehar, Yang, Bing, Xiao, Tony Z., Peters, Noel, Hoffmann, Michael F., Longley, B. Jack
Publicado em 2011

“.... Based on previously published effects of MAGE suppression, we developed a strategy for screening a small...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

159

A carregar...

Ultra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein-Protein Interactions

Por Johnson, David K., Karanicolas, John
Publicado no J Chem Inf Model (2016)

“... speed advantage over docking: 6 million compounds can be screened in about 15 minutes on a single 16...”
Obter o texto integral
Obter o texto integral
Obter o texto integral

Artigo

160

A carregar...

Small Molecular Drug Transfer across the Blood-Brain Barrier via Carrier-Mediated Transport Systems

Por Tsuji, Akira
Publicado em 2005

“... progressed rapidly. Therefore, the BBB is now considered to be a dynamic interface that controls the influx...”
Obter o texto integral
Obter o texto integral

Artigo

Refinar a Pesquisa