Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel compounds with various activities. We isolated stellettin B (Stel B) from marine sponge Jaspis stellifera, and demonstrated that it induced...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Ran, Zhang, Qian, Peng, Xin, Zhou, Chang, Zhong, Yuxu, Chen, Xi, Qiu, Yuling, Jin, Meihua, Gong, Min, Kong, Dexin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886687/
https://ncbi.nlm.nih.gov/pubmed/27243769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27071
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