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Identification of novel small molecules that inhibit protein–protein interactions between MAGE and KAP-1
The Class I MAGE proteins are normally expressed only in developing germ cells but are often aberrantly expressed in malignancies, particularly melanoma, making them good therapeutic targets. MAGE proteins promote tumor survival by binding to the RBCC region of KAP-1 and suppressing p53. Although, s...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149886/ https://ncbi.nlm.nih.gov/pubmed/21277283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.01.007 |
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