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MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity
Expression of Melanoma AntiGen Encoding (MAGE) genes, particularly MAGE-A3, has been correlated with aggressive clinical course, the acquisition of resistance to chemotherapy and poor clinical outcomes of melanoma and other malignancies. MAGE proteins bind to KAP1, a gene repressor and ubiquitin E3...
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| Publié dans: | Arch Biochem Biophys |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4221552/ https://ncbi.nlm.nih.gov/pubmed/25107531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.07.026 |
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