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MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity

Expression of Melanoma AntiGen Encoding (MAGE) genes, particularly MAGE-A3, has been correlated with aggressive clinical course, the acquisition of resistance to chemotherapy and poor clinical outcomes of melanoma and other malignancies. MAGE proteins bind to KAP1, a gene repressor and ubiquitin E3...

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Détails bibliographiques
Publié dans:Arch Biochem Biophys
Auteurs principaux: Xiao, Tony Z, Suh, Yewseok, Longley, B Jack
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221552/
https://ncbi.nlm.nih.gov/pubmed/25107531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.07.026
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