KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

Krüppel-associated box domain-zinc finger proteins (KRAB–ZFPs) are tetrapod-specific transcriptional repressors encoded in the hundreds by the human genome. In order to explore their as yet ill-defined impact on gene expression, we developed an ectopic repressor assay, allowing the study of KRAB–med...

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Bibliographic Details
Main Authors: Groner, Anna C., Meylan, Sylvain, Ciuffi, Angela, Zangger, Nadine, Ambrosini, Giovanna, Dénervaud, Nicolas, Bucher, Philipp, Trono, Didier
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832679/
https://ncbi.nlm.nih.gov/pubmed/20221260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000869
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