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Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

Nucleocytoplasmic transport of macromolecules is a fundamental process of eukaryotic cells. Translocation of proteins and many RNAs between the nucleus and cytoplasm is carried out by shuttling receptors of the β-karyopherin family, also called importins and exportins. Leptomycin B, a small molecule...

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Detalhes bibliográficos
Main Authors: Ambrus, Géza, Whitby, Landon R., Singer, Eric L., Trott, Oleg, Choi, Euna, Olson, Arthur J., Boger, Dale L., Gerace, Larry
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966498/
https://ncbi.nlm.nih.gov/pubmed/20869252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.08.038
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