Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD...

Por David C. Norris
Publicado em 2017-03-01

THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL...

Por Lam, Fred C, Vu-Han, Tu-Lan, Van de Kooj, Bert, Kong, Yi Wen, Bandopadhayay, Pratiti, Beroukhim, Rameen, Sarkaria, Jann, Hammond, Paula, Yaffe, Michael
Publicado no Neuro Oncol (2019)

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

Por Kim, Yo Han, Choi, Hee Youn, Lim, Hyeong-Seok, Lee, Shi Hyang, Jeon, Hae Sun, Hong, Donghyun, Kim, Seong Su, Choi, Young Kweon, Bae, Kyun-Seop
Publicado no Drug Des Devel Ther (2015)

Novel Strategies for Anterior Segment Ocular Drug Delivery

Por Cholkar, Kishore, Patel, Sulabh P., Vadlapudi, Aswani Dutt, Mitra, Ashim K.
Publicado em 2013

Brivaracetam: a novel antiepileptic drug for focal-onset seizures

Por Stephen, Linda J., Brodie, Martin J.
Publicado no Ther Adv Neurol Disord (2017)

Biological activity of catecholamines covalently linked to synthetic polymers: proof of immobilized drug theory.

Por Verlander, M S, Venter, J C, Goodman, M, Kaplan, N O, Saks, B
Publicado em 1976

Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring

Por Alhameed, Abrar F, Khansa, Sara Al, Hasan, Hani, Ismail, Sherine, Aseeri, Mohammed
Publicado no Pharmacy (Basel) (2019)

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

Por Kim, Yo Han, Choi, Hee Youn, Lee, Shi Hyang, Lim, Hyeong-Seok, Miki, Tokutaro, Kang, Jong-Koo, Han, Kyoung-Goo, Bae, Kyun-Seop
Publicado no Drug Des Devel Ther (2015)

Individualized Drug Dosing using RBF-Galerkin Method: Case of Anemia Management in Chronic Kidney Disease

Por Mirinejad, Hossein, Gaweda, Adam E., Brier, Michael E., Zurada, Jacek M., Inanc, Tamer
Publicado no Comput Methods Programs Biomed (2017)

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Por Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
Publicado no J Pharmacol Exp Ther (2016)

Differences in Methylphenidate Dose Response between Periadolescent and Adult Rats in the Familiar Arena-Novel Alcove Task

Por Levant, Beth, Zarcone, Troy J., Davis, Paul F., Ozias, Marlies K., Fowler, Stephen C.
Publicado em 2011

Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation

Por Hayashi, Tomoko, Crain, Brian, Yao, Shiyin, Caneda, Christa D., Cottam, Howard B., Chan, Michael, Corr, Maripat, Carson, Dennis A.
Publicado em 2014

Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis

Por Zhang, Haoming, Lauver, D. Adam, Wang, Hui, Sun, Duxin, Hollenberg, Paul F., Chen, Y. Eugene, Osawa, Yoichi, Eitzman, Daniel T.
Publicado no J Pharmacol Exp Ther (2016)

Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders

Por Kalinichev, Mikhail, Le Poul, Emmanuel, Boléa, Christelle, Girard, Françoise, Campo, Brice, Fonsi, Massimiliano, Royer-Urios, Isabelle, Browne, Susan E., Uslaner, Jason M., Davis, Matthew J., Raber, Jacob, Duvoisin, Robert, Bate, Simon T., Reynolds, Ian J., Poli, Sonia, Celanire, Sylvain
Publicado em 2014

Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649

Por Skarke, C, Alamuddin, N, Lawson, JA, Cen, L, Propert, KJ, FitzGerald, GA
Publicado em 2012

Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

Por Sunwoo, Jung, Kim, Yu Kyong, Choi, Yewon, Yu, Kyung-Sang, Nam, Heesook, Cho, Young Lag, Yoon, Seonghae, Chung, Jae-Yong
Publicado no Drug Des Devel Ther (2018)

Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers

Por Gu, Namyi, Park, Min Kyu, Kim, Tae-Eun, Bahng, Mi Young, Lim, Kyoung Soo, Cho, Sang-Heon, Yoon, Seo Hyun, Cho, Joo-Youn, Jang, In-Jin, Yu, Kyung-Sang
Publicado em 2014

Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization

Por Wang, Wei-Peng, Ho, Pui Yan, Chen, Qiu-Xia, Addepalli, Balasubrahmanyam, Limbach, Patrick A., Li, Mei-Mei, Wu, Wen-Juan, Jilek, Joseph L., Qiu, Jing-Xin, Zhang, Hong-Jian, Li, Tianhong, Wun, Theodore, White, Ralph DeVere, Lam, Kit S., Yu, Ai-Ming
Publicado no J Pharmacol Exp Ther (2015)

A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction

Por Hay, Meredith, Polt, Robin, Heien, Michael L., Vanderah, Todd W., Largent-Milnes, Tally M., Rodgers, Kathleen, Falk, Torsten, Bartlett, Mitchell J., Doyle, Kristian P., Konhilas, John P.
Publicado no J Pharmacol Exp Ther (2019)

Fixed-dose Sumatriptan/Naproxen Sodium Compared with each Monotherapy Utilizing...

Por Landy, Stephen, White, Jonathan, Lener, Shelly E., McDonald, Susan A.
Publicado em 2009