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Biological activity of catecholamines covalently linked to synthetic polymers: proof of immobilized drug theory.
l-Isoproterenol was covalently coupled via an azo linkage to soluble copolypeptides of molecular weight 1500 and 10,000 containing an aromatic amine. The polymeric azo-isoproterenol derivatives were purified by gel chromatography which reduced contamination by the parent isoproterenol to undetectabl...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1976
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1063386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.4.1009 |
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