Bioengineering Novel Chimeric microRNA-34a for Prodrug Cancer Therapy: High-Yield Expression and Purification, and Structural and Functional Characterization

Development of anticancer treatments based on microRNA (miRNA/miR) such as miR-34a replacement therapy is limited to the use of synthetic RNAs with artificial modifications. Herein, we present a new approach to a high-yield and large-scale biosynthesis, in Escherichia coli using transfer RNA (tRNA)...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Wang, Wei-Peng, Ho, Pui Yan, Chen, Qiu-Xia, Addepalli, Balasubrahmanyam, Limbach, Patrick A., Li, Mei-Mei, Wu, Wen-Juan, Jilek, Joseph L., Qiu, Jing-Xin, Zhang, Hong-Jian, Li, Tianhong, Wun, Theodore, White, Ralph DeVere, Lam, Kit S., Yu, Ai-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518075/
https://ncbi.nlm.nih.gov/pubmed/26022002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225631
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