Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity

In contrast to the growing interests in studying noncoding RNAs (ncRNAs) such as microRNA (miRNA or miR) pharmacoepigenetics, there is a lack of efficient means to cost effectively produce large quantities of natural miRNA agents. Our recent efforts led to a successful production of chimeric pre-miR...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Li, Mei-Mei, Addepalli, Balasubrahmanyam, Tu, Mei-Juan, Chen, Qiu-Xia, Wang, Wei-Peng, Limbach, Patrick A., LaSalle, Janine M., Zeng, Su, Huang, Min, Yu, Ai-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468437/
https://ncbi.nlm.nih.gov/pubmed/25934574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.064493
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