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MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis

Cancer cells are dysregulated and addicted to continuous supply and metabolism of nutritional glucose and amino acids (e.g., arginine) to drive the synthesis of critical macromolecules for uncontrolled growth. Recent studies have revealed that genome-derived microRNA (miRNA or miR)-1291-5p (miR-1291...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Tu, Mei-Juan, Duan, Zhijian, Liu, Zhenzhen, Zhang, Chao, Bold, Richard J., Gonzalez, Frank J., Kim, Edward J., Yu, Ai-Ming
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673485/
https://ncbi.nlm.nih.gov/pubmed/33051382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000130
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