MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis

Cancer cells are dysregulated and addicted to continuous supply and metabolism of nutritional glucose and amino acids (e.g., arginine) to drive the synthesis of critical macromolecules for uncontrolled growth. Recent studies have revealed that genome-derived microRNA (miRNA or miR)-1291-5p (miR-1291...

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Bibliographic Details
Published in:Mol Pharmacol
Main Authors: Tu, Mei-Juan, Duan, Zhijian, Liu, Zhenzhen, Zhang, Chao, Bold, Richard J., Gonzalez, Frank J., Kim, Edward J., Yu, Ai-Ming
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673485/
https://ncbi.nlm.nih.gov/pubmed/33051382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000130
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