Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead

Por Eduardo M. Bruch, Stéphanie Petrella, Marco Bellinzoni
Publicado em 2020-06-01

Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis...

Por de Welzen, Lynne, Eldholm, Vegard, Maharaj, Kashmeel, Manson, Abigail L., Earl, Ashlee M., Pym, Alexander S.
Publicado no Antimicrob Agents Chemother (2017)

The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment

Por Saint-Léger, Adélaïde, Sinadinos, Christopher, Ribas de Pouplana, Lluís
Publicado no Bioengineered (2016)

Preclinical pharmacology, antitumor activity and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930

Por Yap, Timothy A., Walton, Mike I., Hunter, Lisa-Jane K., Valenti, Melanie, de Haven Brandon, Alexis, Eve, Paul D., Ruddle, Ruth, Heaton, Simon P., Henley, Alan, Pickard, Lisa, Vijayaraghavan, Gowri, Caldwell, John J., Thompson, Neil T., Aherne, Wynne, Raynaud, Florence I., Eccles, Suzanne A., Workman, Paul, Collins, Ian, Garrett, Michelle D.
Publicado no Mol Cancer Ther (2010)

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Por Seo, Kyoung Duck, Choi, Andrew, Doh, Junsang, Kim, Dong Sung
Publicado no J Vis Exp (2016)

14-3-3ε Boosts Bleomycin-induced DNA Damage Response by Inhibiting the Drug-Resistant Activity of MVP

Por Tang, Siwei, Bai, Chen, Yang, Pengyuan, Chen, Xian
Publicado em 2013

Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer

Por Destouches, Damien, Sader, Maha, Terry, Stéphane, Marchand, Charles, Maillé, Pascale, Soyeux, Pascale, Carpentier, Gilles, Semprez, Fannie, Céraline, Jocelyn, Allory, Yves, Courty, José, De La Taille, Alexandre, Vacherot, Francis
Publicado no Oncotarget (2016)

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

Por Novoa, Eva Maria, Camacho, Noelia, Tor, Anna, Wilkinson, Barrie, Moss, Steven, Marín-García, Patricia, Azcárate, Isabel G., Bautista, José M., Mirando, Adam C., Francklyn, Christopher S., Varon, Sònia, Royo, Miriam, Cortés, Alfred, Ribas de Pouplana, Lluís
Publicado no Proc Natl Acad Sci U S A (2014)

A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus.

Por Trucksis, M, Wolfson, J S, Hooper, D C
Publicado em 1991

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae.

Por Pan, X S, Ambler, J, Mehtar, S, Fisher, L M
Publicado em 1996

Expanding the spectrum of PEX16 mutations and novel insights into disease mechanisms

Por Kishore R. Kumar, Gautam Wali, Ryan L. Davis, Amali C. Mallawaarachchi, Elizabeth E. Palmer, Velimir Gayevskiy, Andre E. Minoche, David Veivers, Marcel E. Dinger, Alan Mackay-Sim, Mark J. Cowley, Carolyn M. Sue
Publicado em 2018-09-01

Molecular Characterization of Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Strains in Jiangxi, China

Por Yuan, Xiaoliang, Zhang, Tiantuo, Kawakami, Kazuyoshi, Zhu, Jiaxin, Li, Hongtao, Lei, Jianping, Tu, Shaohua
Publicado em 2012

Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions

Por Brichkina, A, Nguyen, N TM, Baskar, R, Wee, S, Gunaratne, J, Robinson, R C, Bulavin, D V
Publicado no Cell Death Differ (2016)

Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates

Por Maningi, Nontuthuko E., Daum, Luke T., Rodriguez, John D., Said, Halima M., Peters, Remco P. H., Sekyere, John Osei, Fischer, Gerald W., Chambers, James P., Fourie, P. Bernard
Publicado no J Clin Microbiol (2018)

LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors

Por Wang, Yi-Shu, Chen, Jianfeng, Cui, Fengmei, Wang, Huibo, Wang, Shuai, Hang, Wei, Zeng, Qinghua, Quan, Cheng-Shi, Zhai, Ying-Xian, Wang, Jian-Wei, Shen, Xiang-Feng, Jian, Yong-Ping, Zhao, Rui-Xun, Werle, Kaitlin D., Cui, Rutao, Liang, Jiyong, Li, Yu-Lin, Xu, Zhi-Xiang
Publicado no Oncotarget (2016)

Proteolytic cleavage of p70 ribosomal S6 kinase by caspase-3 during DNA damage-induced apoptosis

Por Dhar, Rohini, Persaud, Shalini D., Mireles, Joe R., Basu, Alakananda
Publicado em 2009

Determining Genotypic Drug Resistance by Ion Semiconductor Sequencing With the Ion AmpliSeq™ TB...

Por Park, Joonhong, Shin, So Youn, Kim, Kyungjong, Park, Kuhn, Shin, Soyoung, Ihm, Chunhwa
Publicado no Ann Lab Med (2018)

The Road Ahead to Cure Alzheimer’s Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations

Por Cavedo, E., Lista, S., Khachaturian, Z., Aisen, P., Amouyel, P., Herholz, K., Jack, C.R., Sperling, R., Cummings, J., Blennow, K., O’Bryant, S., Frisoni, G.B., Khachaturian, A., Kivipelto, M., Klunk, W., Broich, K., Andrieu, S., de Schotten, M. Thiebaut, Mangin, J.-F., Lammertsma, A.A., Johnson, K., Teipel, S., Drzezga, A., Bokde, A., Colliot, O., Bakardjian, H., Zetterberg, H., Dubois, B., Vellas, B., Schneider, L.S., Hampel, H.
Publicado no J Prev Alzheimers Dis (2014)

Identification of novel functional Organic Anion-transporting Polypeptide 1B3 (OATP1B3) polymorphisms and assessment of substrate specificity

Por Schwarz, Ute I., Meyer zu Schwabedissen, Henriette E., Tirona, Rommel G., Suzuki, Atsuko, Leake, Brenda F., Mokrab, Younes, Mizuguchi, Kenji, Ho, Richard H., Kim, Richard B.
Publicado em 2011

IUTAM symposium on modelling nanomaterials and nanosystems proceedings of the IUTAM symposium held in Aalborg, Denmark, 19-22 May, 2008 /

Por IUTAM Symposium on Modelling Nanomaterials and Nanosystems, Pyrz, R., Rauhe, Jens Christian M.
Publicado em 2009