Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions

The stress-induced p38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in multiple physiological processes, including cancer. In turn, p38MAPK phosphorylation at Thr180 and Tyr182 is a key regulatory mechanism for its activation and functions. Here we show that this mechanism...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Brichkina, A, Nguyen, N TM, Baskar, R, Wee, S, Gunaratne, J, Robinson, R C, Bulavin, D V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041188/
https://ncbi.nlm.nih.gov/pubmed/27233083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.45
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