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Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

Malaria remains a major global health problem. Emerging resistance to existing antimalarial drugs drives the search for new antimalarials, and protein translation is a promising pathway to target. Here we explore the potential of the aminoacyl-tRNA synthetase (ARS) family as a source of antimalarial...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Novoa, Eva Maria, Camacho, Noelia, Tor, Anna, Wilkinson, Barrie, Moss, Steven, Marín-García, Patricia, Azcárate, Isabel G., Bautista, José M., Mirando, Adam C., Francklyn, Christopher S., Varon, Sònia, Royo, Miriam, Cortés, Alfred, Ribas de Pouplana, Lluís
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280603/
https://ncbi.nlm.nih.gov/pubmed/25489076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405994111
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