Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-angiogenic AARS. Angiogenesis stimulation can be blocked by...

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Publicado en:Sci Rep
Autores principales: Mirando, Adam C., Fang, Pengfei, Williams, Tamara F., Baldor, Linda C., Howe, Alan K., Ebert, Alicia M., Wilkinson, Barrie, Lounsbury, Karen M., Guo, Min, Francklyn, Christopher S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536658/
https://ncbi.nlm.nih.gov/pubmed/26271225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13160
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