Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor

Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These include angiogenesis, and human threonyl-tRNA synthetase (TARS) represents a potent pro-angiogenic AARS. Angiogenesis stimulation can be blocked by...

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發表在:Sci Rep
Main Authors: Mirando, Adam C., Fang, Pengfei, Williams, Tamara F., Baldor, Linda C., Howe, Alan K., Ebert, Alicia M., Wilkinson, Barrie, Lounsbury, Karen M., Guo, Min, Francklyn, Christopher S.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536658/
https://ncbi.nlm.nih.gov/pubmed/26271225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13160
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