Synthesis of dicationic diaryltriazines nucleic acid binding agents

Por Spychala, J, Boykin, DW, Wilson, WD, Zhao, M, Tidwell, RR, Dykstra, CC, Hall, JE, Jones, SK, Schinazi, RF
Publicado em 1994

Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol

Por Gabrielsen, Mari, Kurczab, Rafał, Ravna, Aina W., Kufareva, Irina, Abagyan, Ruben, Chilmonczyk, Zdzisław, Bojarski, Andrzej J., Sylte, Ingebrigt
Publicado em 2011

Design, Synthesis and Biological Evaluation of Biphenylamide Derivatives as Hsp90 C-terminal Inhibitors

Por Zhao, Huiping, Garg, Gaurav, Zhao, Jinbo, Moroni, Elisabetta, Girgis, Antwan, Franco, Lucas S., Singh, Swapnil, Colombo, Giorgio, Blagg, Brian S. J.
Publicado no Eur J Med Chem (2014)

(E)-4-aryl-4-oxo-2-butenoic acid amides, chalcone–aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization

Por Vitorović-Todorović, Maja D., Erić-Nikolić, Aleksandra, Kolundžija, Branka, Hamel, Ernest, Ristić, Slavica, Juranić, Ivan O., Drakulić, Branko J.
Publicado em 2013

Design, Synthesis and Biological Evaluations of N-Hydroxy thienopyrimidine-2,4-diones as Inhibitors of HIV Reverse Transcriptase-Associated RNase H

Por Kankanala, Jayakanth, Kirby, Karen A., Huber, Andrew D., Casey, Mary C., Wilson, Daniel J., Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2017)

Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4

Por Madadi, Nikhil R., Penthala, Narsimha R., Howk, Kevin, Ketkar, Amit, Eoff, Robert L., Borrelli, Michael J., Crooks, Peter A.
Publicado no Eur J Med Chem (2015)

Synthesis of dicationic diarylpyridines as nucleic-acid binding agents

Por Kumar, A, Rhodes, RA, Spychala, J, Wilson, WD, Boykin, DW, Tidwell, RR, Dykstra, CC, Hall, JE, Jones, SK, Schinazi, RF
Publicado em 1995

From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation

Por Zhong, Bo, Cai, Xiaohan, Chennamaneni, Snigdha, Yi, Xin, Liu, lili, Pink, John J., Dowlati, Afshin, Xu, Yan, Zhou, Aimin, Su, Bin
Publicado em 2011

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an Inhibitor Scaffold of HIV Reverase Transcriptase: Impacts of the 3-OH on Inhibiting RNase H and Polymerase

Por Tang, Jing, Kirby, Karen A., Huber, Andrew D., Casey, Mary C., Ji, Juan, Wilson, Daniel J., Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2017)

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophen...

Por Vallone, Alessandra, D’Alessandro, Sarah, Brogi, Simone, Brindisi, Margherita, Chemi, Giulia, Alfano, Gloria, Lamponi, Stefania, Lee, Soon Goo, Jez, Joseph M., Koolen, Karin J.M., Dechering, Koen J., Saponara, Simona, Fusi, Fabio, Gorelli, Beatrice, Taramelli, Donatella, Parapini, Silvia, Caldelari, Reto, Campiani, Giuseppe, Gemma, Sandra, Butini, Stefania
Publicado no Eur J Med Chem (2018)

Design, Synthesis and Biological Evaluation of WC-9 Analogues as Antiparasitic Agents

Por Elicio, Pablo D., Chao, María N., Galizzi, Melina, Li, Catherine, Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Publicado em 2013

Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity

Por Chorell, Erik, Bengtsson, Christoffer, Banchelin, Thomas Sainte-Luce, Das, Pralay, Uvell, Hanna, Sinha, Arun K., Pinkner, Jerome S., Hultgren, Scott J., Almqvist, Fredrik
Publicado em 2011

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

Por Amblard, Franck, Fromentin, Emilie, Detorio, Mervi, Obikhod, Alexander, Rapp, Kimberly L., McBrayer, Tamara R., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Publicado em 2009

Small lipidated anti-obesity compounds derived from neuromedin U

Por Micewicz, Ewa D., Bahattab, Omar S.O., Willars, Gary B., Waring, Alan J., Navab, Mohamad, Whitelegge, Julian P., McBride, William H., Ruchala, Piotr
Publicado no Eur J Med Chem (2015)

Evaluation of 2-Thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA Activators

Por Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Sidransky, Ellen, Aungst, Ronald A., Liu, Ke, Sadhukhan, Subir Kumar, Austin, Christopher P.
Publicado em 2010

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

Por Wang, Lei, Tang, Jing, Huber, Andrew, Casey, Mary, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Publicado no Eur J Med Chem (2018)

Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors

Por Jarończyk, Małgorzata, Wołosewicz, Karol, Gabrielsen, Mari, Nowak, Gabriel, Kufareva, Irina, Mazurek, Aleksander P., Ravna, Aina W., Abagyan, Ruben, Bojarski, Andrzej J., Sylte, Ingebrigt, Chilmonczyk, Zdzisław
Publicado em 2012

Design, Synthesis and Biological Evaluation of Sulfur-Containing 1,1-Bisphosphonic Acids as Antiparasitic Agents

Por Recher, Marion, Barboza, Alejandro P., Li, Zhu-Hong, Galizzi, Melina, Ferrer-Casal, Mariana, Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Publicado em 2012

Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogues for boron neutron capture therapy of cancer

Por Agarwal, Hitesh K., Khalil, Ahmed, Ishita, Keisuke, Yang, Weilian, Nakkula, Robin J., Wu, Lai-Chu, Ali, Tehane, Tiwari, Rohit, Byun, Youngjoo, Barth, Rolf F., Tjarks, Werner
Publicado no Eur J Med Chem (2015)

New Highly Active Antiplatelet Agents with Dual Specificity for Platelet P2Y(1) and P2Y(12) Adenosine Diphosphate Receptors

Por Yanachkov, Ivan B., Chang, Hung, Yanachkova, Milka I., Dix, Edward J., Berny-Lang, Michelle A., Gremmel, Thomas, Michelson, Alan D., Wright, George E., Frelinger, Andrew L.
Publicado no Eur J Med Chem (2015)