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Design, Synthesis and Biological Evaluation of Biphenylamide Derivatives as Hsp90 C-terminal Inhibitors

Modulation of Hsp90 C-terminal function represents a promising therapeutic approach for the treatment of cancer and neurodegenerative diseases. Current drug discovery efforts toward Hsp90 C-terminal inhibition focus on novobiocin, an antibiotic that was transformed into an Hsp90 inhibitor. Based on...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Eur J Med Chem
Päätekijät: Zhao, Huiping, Garg, Gaurav, Zhao, Jinbo, Moroni, Elisabetta, Girgis, Antwan, Franco, Lucas S., Singh, Swapnil, Colombo, Giorgio, Blagg, Brian S. J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406240/
https://ncbi.nlm.nih.gov/pubmed/25462258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.10.034
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