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Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors

Inhibition of the heat shock protein 90 (Hsp90) C-terminus represents a promising therapeutic strategy for the treatment of cancer. Novobiocin, a coumarin antibiotic, was the first Hsp90 C-terminal inhibitor identified, however, it manifested poor anti-proliferative activity (SKBr3, IC(50) ~ 700 μM)...

詳細記述

保存先:
書誌詳細
出版年:Chemistry
主要な著者: Garg, Gaurav, Forsberg, Leah K., Zhao, Huiping, Blagg, Brian S. J.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724527/
https://ncbi.nlm.nih.gov/pubmed/28940589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201703206
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