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Modified Biphenyl Hsp90 C-terminal Inhibitors for the Treatment of Cancer
Heat shock protein 90 (Hsp90) is a chaperone under investigation for the treatment of neurodegenerative diseases and cancer. Neuroprotective Hsp90 C-terminal inhibitors (novologues) contain a biaryl ring system, and include KU-596, which was modified and investigated for potential anti-cancer activi...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5876719/ https://ncbi.nlm.nih.gov/pubmed/28844386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.07.030 |
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