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Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide-binding Pocket

The 90 kDa heal shock proteins (Hsp90), which are integrally involved in cell signaling, proliferation, and survival, are ubiquitously expressed in cells. Many proteins in tumor cells are dependent upon the Hsp90 protein folding machinery for their stability, refolding, and maturation. Inhibition of...

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Bibliografiske detaljer
Main Authors: Donnelly, Alison, Blagg, Brian S. J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729083/
https://ncbi.nlm.nih.gov/pubmed/18991631
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