Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells

[Image: see text] Human Hsp90 isoforms are molecular chaperones that are often up-regulated in malignances and represent a primary target for Hsp90 inhibitors undergoing clinical evaluation. Hsp90α is a stress-inducible isoform of Hsp90 that plays a significant role in apoptosis and metastasis. Thou...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Ghosh, Suman, Shinogle, Heather E., Garg, Gaurav, Vielhauer, George A., Holzbeierlein, Jeffrey M., Dobrowsky, Rick T., Blagg, Brian S. J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340358/
https://ncbi.nlm.nih.gov/pubmed/25402753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5008713
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