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3′-Phosphodiesterase and 3′→5′ Exonuclease Activities of Yeast Apn2 Protein and Requirement of These Activities for Repair of Oxidative DNA Damage

In Saccharomyces cerevisiae, the AP endonucleases encoded by the APN1 and APN2 genes provide alternate pathways for the removal of abasic sites. Oxidative DNA-damaging agents, such as H(2)O(2), produce DNA strand breaks which contain 3′-phosphate or 3′-phosphoglycolate termini. Such 3′ termini are i...

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Udgivet i:Mol Cell Biol
Principais autores: Unk, Ildiko, Haracska, Lajos, Prakash, Satya, Prakash, Louise
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86711/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238902/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.5.1656-1661.2001
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