3′-Phosphodiesterase and 3′→5′ Exonuclease Activities of Yeast Apn2 Protein and Requirement of These Activities for Repair of Oxidative DNA Damage

In Saccharomyces cerevisiae, the AP endonucleases encoded by the APN1 and APN2 genes provide alternate pathways for the removal of abasic sites. Oxidative DNA-damaging agents, such as H(2)O(2), produce DNA strand breaks which contain 3′-phosphate or 3′-phosphoglycolate termini. Such 3′ termini are i...

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Main Authors: Unk, Ildiko, Haracska, Lajos, Prakash, Satya, Prakash, Louise
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC86711/
https://ncbi.nlm.nih.gov/pubmed/11238902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1656-1661.2001
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