3′-Phosphodiesterase and 3′→5′ Exonuclease Activities of Yeast Apn2 Protein and Requirement of These Activities for Repair of Oxidative DNA Damage

In Saccharomyces cerevisiae, the AP endonucleases encoded by the APN1 and APN2 genes provide alternate pathways for the removal of abasic sites. Oxidative DNA-damaging agents, such as H(2)O(2), produce DNA strand breaks which contain 3′-phosphate or 3′-phosphoglycolate termini. Such 3′ termini are i...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Unk, Ildiko, Haracska, Lajos, Prakash, Satya, Prakash, Louise
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2001
Materias:	DNA Dynamics and Chromosome Structure
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.5.1656-1661.2001
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