TCR β chain–directed bispecific antibodies for the treatment of T cell cancers

Immunotherapies such as chimeric antigen receptor (CAR) T cells and bispecific antibodies redirect healthy T cells to kill cancer cells expressing the target antigen. The pan-B cell antigen–targeting immunotherapies have been remarkably successful in treating B cell malignancies. Such therapies also...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Paul, Suman, Pearlman, Alexander H., Douglass, Jacqueline, Mog, Brian J., Hsiue, Emily Han-Chung, Hwang, Michael S., DiNapoli, Sarah R., Konig, Maximilian F., Brown, Patrick A., Wright, Katharine M., Sur, Surojit, Gabelli, Sandra B., Li, Yana, Ghiaur, Gabriel, Pardoll, Drew M., Papadopoulos, Nickolas, Bettegowda, Chetan, Kinzler, Kenneth W., Zhou, Shibin, Vogelstein, Bert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236299/
https://ncbi.nlm.nih.gov/pubmed/33649188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd3595
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