TCR β chain–directed bispecific antibodies for the treatment of T cell cancers

Immunotherapies such as chimeric antigen receptor (CAR) T cells and bispecific antibodies redirect healthy T cells to kill cancer cells expressing the target antigen. The pan-B cell antigen–targeting immunotherapies have been remarkably successful in treating B cell malignancies. Such therapies also...

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Bibliographic Details
Published in:Sci Transl Med
Main Authors: Paul, Suman, Pearlman, Alexander H., Douglass, Jacqueline, Mog, Brian J., Hsiue, Emily Han-Chung, Hwang, Michael S., DiNapoli, Sarah R., Konig, Maximilian F., Brown, Patrick A., Wright, Katharine M., Sur, Surojit, Gabelli, Sandra B., Li, Yana, Ghiaur, Gabriel, Pardoll, Drew M., Papadopoulos, Nickolas, Bettegowda, Chetan, Kinzler, Kenneth W., Zhou, Shibin, Vogelstein, Bert
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236299/
https://ncbi.nlm.nih.gov/pubmed/33649188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd3595
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