Bispecific antibodies targeting mutant RAS neoantigens

Mutations in the RAS oncogenes occur in multiple cancers, and ways to target these mutations has been the subject of intense research for decades. Most of these efforts are focused on conventional small-molecule drugs rather than antibody-based therapies because the RAS proteins are intracellular. P...

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書誌詳細
出版年:Sci Immunol
主要な著者: Douglass, Jacqueline, Hsiue, Emily Han-Chung, Mog, Brian J., Hwang, Michael S., DiNapoli, Sarah R., Pearlman, Alexander H., Miller, Michelle S., Wright, Katharine M., Azurmendi, P. Aitana, Wang, Qing, Paul, Suman, Schaefer, Annika, Skora, Andrew D., Molin, Marco Dal, Konig, Maximilian F., Liu, Qiang, Watson, Evangeline, Li, Yana, Murphy, Michael B., Pardoll, Drew M., Bettegowda, Chetan, Papadopoulos, Nickolas, Gabelli, Sandra B., Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141259/
https://ncbi.nlm.nih.gov/pubmed/33649101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd5515
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