Bispecific antibodies targeting mutant RAS neoantigens

Mutations in the RAS oncogenes occur in multiple cancers, and ways to target these mutations has been the subject of intense research for decades. Most of these efforts are focused on conventional small-molecule drugs rather than antibody-based therapies because the RAS proteins are intracellular. P...

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Publicado en:Sci Immunol
Main Authors: Douglass, Jacqueline, Hsiue, Emily Han-Chung, Mog, Brian J., Hwang, Michael S., DiNapoli, Sarah R., Pearlman, Alexander H., Miller, Michelle S., Wright, Katharine M., Azurmendi, P. Aitana, Wang, Qing, Paul, Suman, Schaefer, Annika, Skora, Andrew D., Molin, Marco Dal, Konig, Maximilian F., Liu, Qiang, Watson, Evangeline, Li, Yana, Murphy, Michael B., Pardoll, Drew M., Bettegowda, Chetan, Papadopoulos, Nickolas, Gabelli, Sandra B., Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141259/
https://ncbi.nlm.nih.gov/pubmed/33649101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd5515
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