Bispecific antibodies targeting mutant RAS neoantigens

Mutations in the RAS oncogenes occur in multiple cancers, and ways to target these mutations has been the subject of intense research for decades. Most of these efforts are focused on conventional small-molecule drugs rather than antibody-based therapies because the RAS proteins are intracellular. P...

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Bibliografski detalji
Izdano u:Sci Immunol
Glavni autori: Douglass, Jacqueline, Hsiue, Emily Han-Chung, Mog, Brian J., Hwang, Michael S., DiNapoli, Sarah R., Pearlman, Alexander H., Miller, Michelle S., Wright, Katharine M., Azurmendi, P. Aitana, Wang, Qing, Paul, Suman, Schaefer, Annika, Skora, Andrew D., Molin, Marco Dal, Konig, Maximilian F., Liu, Qiang, Watson, Evangeline, Li, Yana, Murphy, Michael B., Pardoll, Drew M., Bettegowda, Chetan, Papadopoulos, Nickolas, Gabelli, Sandra B., Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin
Format: Artigo
Jezik:Inglês
Izdano: 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141259/
https://ncbi.nlm.nih.gov/pubmed/33649101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd5515
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