An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Mutations in CTNNB1, the gene encoding β-catenin, are common in colon and liver cancers, the most frequent mutation affecting Ser-45 in β-catenin. Peptides derived from WT β-catenin have previously been shown to be presented on the cell surface as part of major histocompatibility complex (MHC) class...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Miller, Michelle S., Douglass, Jacqueline, Hwang, Michael S., Skora, Andrew D., Murphy, Michael, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin, Gabelli, Sandra B.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916501/
https://ncbi.nlm.nih.gov/pubmed/31690625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010251
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires