An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Mutations in CTNNB1, the gene encoding β-catenin, are common in colon and liver cancers, the most frequent mutation affecting Ser-45 in β-catenin. Peptides derived from WT β-catenin have previously been shown to be presented on the cell surface as part of major histocompatibility complex (MHC) class...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Miller, Michelle S., Douglass, Jacqueline, Hwang, Michael S., Skora, Andrew D., Murphy, Michael, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin, Gabelli, Sandra B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916501/
https://ncbi.nlm.nih.gov/pubmed/31690625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010251
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