Targeting a neoantigen derived from a common TP53 mutation

TP53 (tumor protein p53) is the most commonly mutated cancer driver gene, but drugs that target mutant tumor suppressor genes, such as TP53, are not yet available. Here, we describe the identification of an antibody highly specific to the most common TP53 mutation (R175H, in which arginine at positi...

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Vydáno v:Science
Hlavní autoři: Hsiue, Emily Han-Chung, Wright, Katharine M., Douglass, Jacqueline, Hwang, Michael S., Mog, Brian J., Pearlman, Alexander H., Paul, Suman, DiNapoli, Sarah R., Konig, Maximilian F., Wang, Qing, Schaefer, Annika, Miller, Michelle S., Skora, Andrew D., Azurmendi, P. Aitana, Murphy, Michael B., Liu, Qiang, Watson, Evangeline, Li, Yana, Pardoll, Drew M., Bettegowda, Chetan, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Gabelli, Sandra B., Zhou, Shibin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208645/
https://ncbi.nlm.nih.gov/pubmed/33649166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc8697
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