TCR β chain–directed bispecific antibodies for the treatment of T cell cancers

Immunotherapies such as chimeric antigen receptor (CAR) T cells and bispecific antibodies redirect healthy T cells to kill cancer cells expressing the target antigen. The pan-B cell antigen–targeting immunotherapies have been remarkably successful in treating B cell malignancies. Such therapies also...

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Udgivet i:Sci Transl Med
Main Authors: Paul, Suman, Pearlman, Alexander H., Douglass, Jacqueline, Mog, Brian J., Hsiue, Emily Han-Chung, Hwang, Michael S., DiNapoli, Sarah R., Konig, Maximilian F., Brown, Patrick A., Wright, Katharine M., Sur, Surojit, Gabelli, Sandra B., Li, Yana, Ghiaur, Gabriel, Pardoll, Drew M., Papadopoulos, Nickolas, Bettegowda, Chetan, Kinzler, Kenneth W., Zhou, Shibin, Vogelstein, Bert
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236299/
https://ncbi.nlm.nih.gov/pubmed/33649188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd3595
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