Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown. Here, we used isogenic...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Stem Cell Reports
Autores principales: Okarmus, Justyna, Havelund, Jesper F., Ryding, Matias, Schmidt, Sissel I., Bogetofte, Helle, Heon-Roberts, Rachel, Wade-Martins, Richard, Cowley, Sally A., Ryan, Brent J., Færgeman, Nils J., Hyttel, Poul, Meyer, Morten
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190670/
https://ncbi.nlm.nih.gov/pubmed/34048689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.04.022
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares