Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells

Microglia have recently been established as key regulators of brain development. However, their role in neuronal subtype specification remains largely unknown. Using three different co-culture setups, we show that microglia-secreted factors enhance dopaminergic differentiation of somatic and induced...

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Publicado en:Stem Cell Reports
Autores principales: Schmidt, Sissel Ida, Bogetofte, Helle, Ritter, Louise, Agergaard, Jette Bach, Hammerich, Ditte, Kabiljagic, Amina Arslanagic, Wlodarczyk, Agnieszka, Lopez, Silvia Garcia, Sørensen, Mia Dahl, Jørgensen, Mie Lærkegård, Okarmus, Justyna, Serrano, Alberto Martínez, Kristensen, Bjarne Winther, Freude, Kristine, Owens, Trevor, Meyer, Morten
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878834/
https://ncbi.nlm.nih.gov/pubmed/33482100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.12.011
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