PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Cell Neurosci
Päätekijät: Bogetofte, Helle, Jensen, Pia, Ryding, Matias, Schmidt, Sissel I., Okarmus, Justyna, Ritter, Louise, Worm, Christina S., Hohnholt, Michaela C., Azevedo, Carla, Roybon, Laurent, Bak, Lasse K., Waagepetersen, Helle, Ryan, Brent J., Wade-Martins, Richard, Larsen, Martin R., Meyer, Morten
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624735/
https://ncbi.nlm.nih.gov/pubmed/31333417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00297
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