PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mi...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Bogetofte, Helle, Jensen, Pia, Ryding, Matias, Schmidt, Sissel I., Okarmus, Justyna, Ritter, Louise, Worm, Christina S., Hohnholt, Michaela C., Azevedo, Carla, Roybon, Laurent, Bak, Lasse K., Waagepetersen, Helle, Ryan, Brent J., Wade-Martins, Richard, Larsen, Martin R., Meyer, Morten
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624735/
https://ncbi.nlm.nih.gov/pubmed/31333417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00297
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