PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mi...

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Pubblicato in:Front Cell Neurosci
Autori principali: Bogetofte, Helle, Jensen, Pia, Ryding, Matias, Schmidt, Sissel I., Okarmus, Justyna, Ritter, Louise, Worm, Christina S., Hohnholt, Michaela C., Azevedo, Carla, Roybon, Laurent, Bak, Lasse K., Waagepetersen, Helle, Ryan, Brent J., Wade-Martins, Richard, Larsen, Martin R., Meyer, Morten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624735/
https://ncbi.nlm.nih.gov/pubmed/31333417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00297
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