Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both s...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Okarmus, Justyna, Bogetofte, Helle, Schmidt, Sissel Ida, Ryding, Matias, García-López, Silvia, Ryan, Brent James, Martínez-Serrano, Alberto, Hyttel, Poul, Meyer, Morten
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314796/
https://ncbi.nlm.nih.gov/pubmed/32581291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67091-6
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars