Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown. Here, we used isogenic...

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Xehetasun bibliografikoak
Argitaratua izan da:Stem Cell Reports
Egile Nagusiak: Okarmus, Justyna, Havelund, Jesper F., Ryding, Matias, Schmidt, Sissel I., Bogetofte, Helle, Heon-Roberts, Rachel, Wade-Martins, Richard, Cowley, Sally A., Ryan, Brent J., Færgeman, Nils J., Hyttel, Poul, Meyer, Morten
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190670/
https://ncbi.nlm.nih.gov/pubmed/34048689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.04.022
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