Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown. Here, we used isogenic...

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Publicado en:Stem Cell Reports
Main Authors: Okarmus, Justyna, Havelund, Jesper F., Ryding, Matias, Schmidt, Sissel I., Bogetofte, Helle, Heon-Roberts, Rachel, Wade-Martins, Richard, Cowley, Sally A., Ryan, Brent J., Færgeman, Nils J., Hyttel, Poul, Meyer, Morten
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190670/
https://ncbi.nlm.nih.gov/pubmed/34048689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.04.022
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