Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both s...

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Publicado en:Sci Rep
Main Authors: Okarmus, Justyna, Bogetofte, Helle, Schmidt, Sissel Ida, Ryding, Matias, García-López, Silvia, Ryan, Brent James, Martínez-Serrano, Alberto, Hyttel, Poul, Meyer, Morten
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314796/
https://ncbi.nlm.nih.gov/pubmed/32581291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67091-6
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