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Improved cell therapy protocol for Parkinson’s disease based on differentiation efficiency and safety of hESC-, hiPSC and non-human primate iPSC-derived DA neurons

The main motor symptoms of Parkinson’s disease are due to the loss of dopaminergic (DA) neurons in the ventral midbrain (VM). For the future treatment of Parkinson’s disease with cell transplantation it is important to develop efficient differentiation methods for production of human iPSCs and hESCs...

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Detalhes bibliográficos
Main Authors: Maria, Sundberg, Helle, Bogetofte, Tristan, Lawson, Gaynor, Smith, Arnar, Astradsson, Michele, Moore, Teresia, Osborn, Oliver, Cooper, Roger, Spealman, Penelope, Hallett, Ole, Isacson
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775937/
https://ncbi.nlm.nih.gov/pubmed/23666606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1415
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