Efficient and Accurate Homologous Recombination in hESCs and hiPSCs Using Helper-dependent Adenoviral Vectors

Low efficiencies of gene targeting via homologous recombination (HR) have limited basic research and applications using human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Here, we show highly and equally efficient gene knockout and knock-in at both transcriptionall...

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Detaylı Bibliyografya
Asıl Yazarlar: Aizawa, Emi, Hirabayashi, Yuka, Iwanaga, Yuzuru, Suzuki, Keiichiro, Sakurai, Kenji, Shimoji, Miho, Aiba, Kazuhiro, Wada, Tamaki, Tooi, Norie, Kawase, Eihachiro, Suemori, Hirofumi, Nakatsuji, Norio, Mitani, Kohnosuke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277220/
https://ncbi.nlm.nih.gov/pubmed/22146343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.266
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