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Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines
In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH(+) neurons was decreased in Parkinson’s disease (PD) patient-derived neurons carrying various mutations in PARK2 compar...
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| Published in: | Stem Cell Reports |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4437475/ https://ncbi.nlm.nih.gov/pubmed/25843045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.02.019 |
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