Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson’s Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson’s disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, and integration-free reprogramming, eight of these...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Momcilovic, Olga, Sivapatham, Renuka, Oron, Tal Ronnen, Meyer, Morten, Mooney, Sean, Rao, Mahendra S., Zeng, Xianmin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871453/
https://ncbi.nlm.nih.gov/pubmed/27191603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154890
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