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Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson’s Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson’s disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, and integration-free reprogramming, eight of these...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Momcilovic, Olga, Sivapatham, Renuka, Oron, Tal Ronnen, Meyer, Morten, Mooney, Sean, Rao, Mahendra S., Zeng, Xianmin
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871453/
https://ncbi.nlm.nih.gov/pubmed/27191603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154890
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