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Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson’s Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson’s disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, and integration-free reprogramming, eight of these...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Momcilovic, Olga, Sivapatham, Renuka, Oron, Tal Ronnen, Meyer, Morten, Mooney, Sean, Rao, Mahendra S., Zeng, Xianmin
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871453/
https://ncbi.nlm.nih.gov/pubmed/27191603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154890
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