The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome

Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer’s disease (AD), flaws in the cerebral glucose uptake translate into reduced hexo...

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Veröffentlicht in:Neurotherapeutics
Hauptverfasser: Zuliani, Ilaria, Lanzillotta, Chiara, Tramutola, Antonella, Francioso, Antonio, Pagnotta, Sara, Barone, Eugenio, Perluigi, Marzia, Di Domenico, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116370/
https://ncbi.nlm.nih.gov/pubmed/33258073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00978-4
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