The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome

Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer’s disease (AD), flaws in the cerebral glucose uptake translate into reduced hexo...

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Publicado en:Neurotherapeutics
Main Authors: Zuliani, Ilaria, Lanzillotta, Chiara, Tramutola, Antonella, Francioso, Antonio, Pagnotta, Sara, Barone, Eugenio, Perluigi, Marzia, Di Domenico, Fabio
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2020
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116370/
https://ncbi.nlm.nih.gov/pubmed/33258073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00978-4
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